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Human‑to‑dog transmission of SARS‑CoV‑2, Colombia

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dc.contributor.authorRivero, Ricardo
dc.contributor.authorGaray Montalvo, Evelin
dc.contributor.authorBotero, Yesica
dc.contributor.authorSerrano Coll, Héctor
dc.contributor.authorGastelbondo Pastrana, Bertha Irina
dc.contributor.authorMuñoz, Marina
dc.contributor.authorBallesteros, Nathalia
dc.contributor.authorCastañeda, Sergio
dc.contributor.authorPatiño, Luz Helena
dc.contributor.authorRamírez, Juan David
dc.contributor.authorCalderón Rangel, Alfonso
dc.contributor.authorGuzmán Terán, Camilo Antonio
dc.contributor.authorMartínez Bravo, Caty Milena
dc.contributor.authorAlemán, Ader
dc.contributor.authorArrieta Bernate, German Javier
dc.contributor.authorMattar Velilla, Ameth Salim
dc.contributor.corporatenameCorporación Universitaria del caribe - CECAR
dc.contributor.researchgroupSalud Pública y Auditoría en Salud
dc.date.accessioned2025-08-26T20:36:44Z
dc.date.issued2022
dc.description.abstractSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of the current COVID-19 pandemic, has evolved to have a wide range of hosts, including non-human primates, wild and domestic animals. The ACE2 protein has a high level of conservation and is the common receptor invertebrate species for a viral infection to occur; this receptor could give rise to anthroponotic events. This article describes the first event of symptomatic transmission in Latin America from a human to a dog by the B.1.625 lineage of SARS-CoV-2. We found 21 shared mutations in the complete genomes of viral sequences from owners and dogs. Further phylogenetic and molecular analysis showed that 100% co-localization of the clade helps to understand human-animal transmission. Prediction of the Spike protein structure of the sequenced virus and docking analyzes showed that the E484K mutation in the receptor-binding domain (RBD) could contribute to the viral affinity of dACE2. Therefore, close contact between SARS-CoV-2-infected humans and pets should be avoided to prevent the emergence of novel mutations of public health importance from anthroponotic events.
dc.description.researchareaAuditoría en salud
dc.description.researchareaSalud Pública
dc.format.extent8 páginas
dc.format.mimetypeapplication/pdf
dc.identifier.eissn2045-2322
dc.identifier.urihttps://repositorio.cecar.edu.co/handle/cecar/10741
dc.language.isoeng
dc.publisher.placeColombia
dc.relation.citationendpage8
dc.relation.citationstartpage1
dc.relation.citationvolumeVolumen 12
dc.relation.ispartofjournalScientific Reports
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dc.rightsDerechos reservados - Corporación Universitaria de Caribe - CECAR
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2
dc.rights.licenseAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourcehttps://doi.org/10.1038/s41598-022-11847-9
dc.subject.proposalSARS-CoV-2
dc.subject.proposaltransmission
dc.subject.proposalHuman‑to‑dog
dc.titleHuman‑to‑dog transmission of SARS‑CoV‑2, Colombiaeng
dc.typeArtículo de revista
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.contentText
dc.type.driverinfo:eu-repo/semantics/article
dc.type.redcolhttp://purl.org/redcol/resource_type/ART
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication

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